ID   FIZ1_HUMAN              Reviewed;         496 AA.
AC   Q96SL8; Q6ZMJ7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   05-OCT-2010, entry version 65.
DE   RecName: Full=Flt3-interacting zinc finger protein 1;
DE   AltName: Full=Zinc finger protein 798;
GN   Name=FIZ1; Synonyms=ZNF798;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-391.
RC   TISSUE=Spleen, and Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=12566383; DOI=10.1093/hmg/ddg035;
RA   Mitton K.P., Swain P.K., Khanna H., Dowd M., Apel I.J., Swaroop A.;
RT   "Interaction of retinal bZIP transcription factor NRL with Flt3-
RT   interacting zinc-finger protein Fiz1: possible role of Fiz1 as a
RT   transcriptional repressor.";
RL   Hum. Mol. Genet. 12:365-373(2003).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17924679; DOI=10.1021/pr070152u;
RA   Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
RT   "Improved titanium dioxide enrichment of phosphopeptides from HeLa
RT   cells and high confident phosphopeptide identification by cross-
RT   validation of MS/MS and MS/MS/MS spectra.";
RL   J. Proteome Res. 6:4150-4162(2007).
CC   -!- FUNCTION: May be a transcriptional repressor of NRL function in
CC       photoreceptors. Does not repress CRX-mediated transactivation (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with FLT3 cytoplasmic catalytic domain,
CC       following receptor stimulation, in a kinase-independent manner.
CC       Does not interact with other structurally related receptor
CC       tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with
CC       NRL (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: Contains 11 C2H2-type zinc fingers.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD18728.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
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DR   EMBL; AK027674; BAB55286.1; -; mRNA.
DR   EMBL; AK160385; BAD18728.1; ALT_INIT; mRNA.
DR   EMBL; AC008735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   IPI; IPI00045801; -.
DR   RefSeq; NP_116225.2; -.
DR   UniGene; Hs.515617; -.
DR   ProteinModelPortal; Q96SL8; -.
DR   SMR; Q96SL8; 21-132, 73-250, 360-492, 413-494.
DR   IntAct; Q96SL8; 1.
DR   STRING; Q96SL8; -.
DR   PRIDE; Q96SL8; -.
DR   Ensembl; ENST00000221665; ENSP00000221665; ENSG00000179943.
DR   GeneID; 84922; -.
DR   KEGG; hsa:84922; -.
DR   CTD; 84922; -.
DR   GeneCards; GC19M056102; -.
DR   HGNC; HGNC:25917; FIZ1.
DR   MIM; 609133; gene.
DR   HOGENOM; HBG717200; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q96SL8; -.
DR   NextBio; 75332; -.
DR   ArrayExpress; Q96SL8; -.
DR   Bgee; Q96SL8; -.
DR   CleanEx; HS_FIZ1; -.
DR   Genevestigator; Q96SL8; -.
DR   GermOnline; ENSG00000105066; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR   GO; GO:0005102; F:receptor binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 5.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein;
KW   Polymorphism; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    496       Flt3-interacting zinc finger protein 1.
FT                                /FTId=PRO_0000046937.
FT   ZN_FING      23     45       C2H2-type 1.
FT   ZN_FING      51     73       C2H2-type 2.
FT   ZN_FING      79    101       C2H2-type 3.
FT   ZN_FING     107    130       C2H2-type 4.
FT   ZN_FING     200    222       C2H2-type 5.
FT   ZN_FING     228    250       C2H2-type 6.
FT   ZN_FING     331    352       C2H2-type 7.
FT   ZN_FING     358    381       C2H2-type 8.
FT   ZN_FING     414    436       C2H2-type 9.
FT   ZN_FING     442    464       C2H2-type 10.
FT   ZN_FING     470    492       C2H2-type 11.
FT   MOD_RES      74     74       Phosphothreonine.
FT   VARIANT     391    391       T -> A (in dbSNP:rs7247236).
FT                                /FTId=VAR_060269.
FT   CONFLICT    127    127       K -> R (in Ref. 1; BAB55286).
SQ   SEQUENCE   496 AA;  51996 MW;  D4DD7E435249B0C5 CRC64;
     MDDVPAPTPA PAPPAAAAPR VPFHCSECGK SFRYRSDLRR HFARHTALKP HACPRCGKGF
     KHSFNLANHL RSHTGERPYR CSACPKGFRD STGLLHHQVV HTGEKPYCCL VCELRFSSRS
     SLGRHLKRQH RGVLPSPLQP GPGLPALSAP CSVCCNVGPC SVCGGSGAGG GEGPEGAGAG
     LGSWGLAEAA AAAAASLPPF ACGACARRFD HGRELAAHWA AHTDVKPFKC PRCERDFNAP
     ALLERHKLTH DLQGPGAPPA QAWAAGPGAG PETAGEGTAA EAGDAPLASD RRLLLGPAGG
     GVPKLGGLLP EGGGEAPAPA AAAEPSEDTL YQCDCGTFFA SAAALASHLE AHSGPATYGC
     GHCGALYAAL AALEEHRRVS HGEGGGEEAA TAAREREPAS GEPPSGSGRG KKIFGCSECE
     KLFRSPRDLE RHVLVHTGEK PFPCLECGKF FRHECYLKRH RLLHGTERPF PCHICGKGFI
     TLSNLSRHLK LHRGMD
//