ID   FEZF1_HUMAN             Reviewed;         475 AA.
AC   A0PJY2; A0PJY3; A4D0W3; B4DUP9; B7ZM98;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   05-OCT-2010, entry version 39.
DE   RecName: Full=Fez family zinc finger protein 1;
DE   AltName: Full=Zinc finger protein 312B;
GN   Name=FEZF1; Synonyms=FEZ, ZNF312B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22616434; PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA   Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA   Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA   Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA   Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA   Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA   Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA   Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA   Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA   Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA   Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA   Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA   Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA   Mural R.J., Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=19318583; DOI=10.1158/0008-5472.CAN-08-2240;
RA   Song I.S., Oh N.S., Kim H.T., Ha G.H., Jeong S.Y., Kim J.M., Kim D.I.,
RA   Yoo H.S., Kim C.H., Kim N.S.;
RT   "Human ZNF312b promotes the progression of gastric cancer by
RT   transcriptional activation of the K-ras gene.";
RL   Cancer Res. 69:3131-3139(2009).
CC   -!- FUNCTION: Transcription repressor. Involved in the axonal
CC       projection and proper termination of olfactory sensory neurons
CC       (OSN). Plays a role in rostro-caudal patterning of the
CC       diencephalon and in prethalamic formation. Expression is required
CC       in OSN to cell-autonomously regulate OSN axon projections.
CC       Regulates non-cell-autonomously the layer formation of the
CC       olfactory bulb development and the interneurons. May be required
CC       for correct rostral migration of the interneuron progenitors (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=A0PJY2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A0PJY2-2; Sequence=VSP_026732;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=A0PJY2-3; Sequence=VSP_026733;
CC         Note=Gene prediction based on EST data;
CC   -!- TISSUE SPECIFICITY: Expressed in brain. Little or no expression in
CC       other tissues. Overexpresssed specifically in gastic cancers. A 2-
CC       to 20-fold increase is found in over 50% of gastric cancer
CC       tissues.
CC   -!- MISCELLANEOUS: Triggers oncogenic activity specifically in gastric
CC       tumors through activation of KRAS in the ERK signaling pathway.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 6 C2H2-type zinc fingers.
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DR   EMBL; AK300742; BAG62411.1; -; mRNA.
DR   EMBL; CH236947; EAL24342.1; -; Genomic_DNA.
DR   EMBL; BC127714; AAI27715.1; -; mRNA.
DR   EMBL; BC127715; AAI27716.1; -; mRNA.
DR   EMBL; BC136684; AAI36685.1; -; mRNA.
DR   EMBL; BC144367; AAI44368.1; -; mRNA.
DR   IPI; IPI00376675; -.
DR   IPI; IPI00816263; -.
DR   IPI; IPI00852828; -.
DR   RefSeq; NP_001019784.2; -.
DR   RefSeq; NP_001153736.1; -.
DR   UniGene; Hs.553970; -.
DR   ProteinModelPortal; A0PJY2; -.
DR   SMR; A0PJY2; 258-394, 282-424.
DR   STRING; A0PJY2; -.
DR   PRIDE; A0PJY2; -.
DR   Ensembl; ENST00000442488; ENSP00000411145; ENSG00000128610.
DR   GeneID; 389549; -.
DR   KEGG; hsa:389549; -.
DR   UCSC; uc003vkc.1; human.
DR   UCSC; uc003vkd.1; human.
DR   UCSC; uc003vke.1; human.
DR   CTD; 389549; -.
DR   GeneCards; GC07M121941; -.
DR   HGNC; HGNC:22788; FEZF1.
DR   MIM; 613301; gene.
DR   eggNOG; prNOG04049; -.
DR   HOGENOM; HBG713580; -.
DR   HOVERGEN; HBG098441; -.
DR   InParanoid; A0PJY2; -.
DR   OMA; RGSPNAK; -.
DR   OrthoDB; EOG908QTW; -.
DR   Bgee; A0PJY2; -.
DR   CleanEx; HS_FEZF1; -.
DR   Genevestigator; A0PJY2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Developmental protein;
KW   Differentiation; DNA-binding; Metal-binding; Neurogenesis; Nucleus;
KW   Repeat; Repressor; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    475       Fez family zinc finger protein 1.
FT                                /FTId=PRO_0000295114.
FT   ZN_FING     260    282       C2H2-type 1.
FT   ZN_FING     288    310       C2H2-type 2.
FT   ZN_FING     316    338       C2H2-type 3.
FT   ZN_FING     344    366       C2H2-type 4.
FT   ZN_FING     372    394       C2H2-type 5.
FT   ZN_FING     400    423       C2H2-type 6.
FT   MOTIF        28     43       Engrailed homology 1 repressor (By
FT                                similarity).
FT   COMPBIAS    433    468       Pro-rich.
FT   VAR_SEQ     144    193       Missing (in isoform 2).
FT                                /FTId=VSP_026732.
FT   VAR_SEQ     265    268       Missing (in isoform 3).
FT                                /FTId=VSP_026733.
SQ   SEQUENCE   475 AA;  52038 MW;  A26945A0C4E9316A CRC64;
     MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH FLQGALPKGE
     PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL EAPAAPAAVP SAPAFSCSDL
     LNCALSLKGD LARDALPLQQ YKLVRPRVVN HSSFHAMGAL CYLNRGDGPC HPAAGVNIHP
     VASYFLSSPL HPQPKTYLAE RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM KESAQLLSEK
     IAFKTSDFSR GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA
     STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG KGFHQKGNYK
     NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF TCPTCGKGFC RNFDLKKHVR
     KLHDSSLGLA RTPAGEPGTE PPPPLPQQPP MTLPPLQPPL PTPGPLQPGL HQGHQ
//