ID   EA3L1_HUMAN             Reviewed;         546 AA.
AC   Q3SY89; Q3MI93;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   05-OCT-2010, entry version 49.
DE   RecName: Full=RNA polymerase II transcription factor SIII subunit A3-like-1;
DE   AltName: Full=Elongin-A3-like-1;
DE            Short=EloA3-like-1;
DE   AltName: Full=Transcription elongation factor B polypeptide 3C-like-1;
GN   Name=TCEB3CL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: SIII, also known as elongin, is a general transcription
CC       elongation factor that increases the RNA polymerase II
CC       transcription elongation past template-encoded arresting sites.
CC       Subunit A3 is transcriptionally active but its transcription
CC       activity is not enhanced by binding to the dimeric complex of the
CC       SIII regulatory subunits B and C (elongin BC complex) (By
CC       similarity).
CC   -!- SUBUNIT: Heterotrimer of an A (A1, A2 or A3), B and C subunit (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- DOMAIN: The elongin BC complex binding domain is also known as BC-
CC       box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
CC   -!- SIMILARITY: Contains 1 TFIIS N-terminal domain.
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DR   EMBL; BC103912; AAI03913.1; -; mRNA.
DR   EMBL; BC103913; AAI03914.1; -; mRNA.
DR   IPI; IPI00735473; -.
DR   RefSeq; NP_001094287.1; -.
DR   UniGene; Hs.631677; -.
DR   ProteinModelPortal; Q3SY89; -.
DR   SMR; Q3SY89; 1-78.
DR   Ensembl; ENST00000451265; ENSP00000409932; ENSG00000234298.
DR   GeneID; 728929; -.
DR   KEGG; hsa:728929; -.
DR   UCSC; uc010dnr.1; human.
DR   CTD; 728929; -.
DR   GeneCards; GC18M044548; -.
DR   HGNC; HGNC:31007; TCEB3CL.
DR   eggNOG; prNOG10238; -.
DR   HOGENOM; HBG506141; -.
DR   HOVERGEN; HBG051467; -.
DR   InParanoid; Q3SY89; -.
DR   OMA; MSFLAPS; -.
DR   OrthoDB; EOG95QKZX; -.
DR   NextBio; 128728; -.
DR   CleanEx; HS_TCEB3CL; -.
DR   Genevestigator; Q3SY89; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0030528; F:transcription regulator activity; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR   InterPro; IPR010990; TFIIS/elonginA/CRSP70_N.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF06881; Elongin_A; 1.
DR   Pfam; PF08711; TFIIS; 1.
DR   SUPFAM; SSF47676; TFIIS_conserved; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Nucleus; Transcription; Transcription regulation.
FT   CHAIN         1    546       RNA polymerase II transcription factor
FT                                SIII subunit A3-like-1.
FT                                /FTId=PRO_0000343428.
FT   DOMAIN        5     80       TFIIS N-terminal.
FT   REGION      308    467       Activation domain (By similarity).
FT   REGION      336    345       Interaction with elongin BC (By
FT                                similarity).
FT   COMPBIAS    119    193       Pro-rich.
FT   CONFLICT     56     56       L -> P (in Ref. 1; AAI03913).
FT   CONFLICT    416    416       Y -> C (in Ref. 1; AAI03913).
SQ   SEQUENCE   546 AA;  59758 MW;  1CD4A5087016E278 CRC64;
     MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR KTVKRLRKHQ
     HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG EALQEREKAW GFPENATAPR
     SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE PRAERKRPRM APADSGPHRD PPTRTAPLPM
     PEGPEPAVPG EQPGRGHAHA AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP
     VQESQSERLQ AAGADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL
     SAPTLQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD ALGDVEGVPY
     SVLEPVLEGW TPDQPYRTEK DNAALARETD ELWRIHCLQD FKEEKPQEHE SWRELYLRLR
     DAREQRLRVV TTKIRSAREN KPSGRQTKMI CFNSVAKTPY DASRRQEKSA GAADPGNGEM
     EPAPKPAGSS QAPSGLGDGD GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK
     GRFSRR
//