ID   CBX7_HUMAN              Reviewed;         251 AA.
AC   O95931; Q86T17;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   05-OCT-2010, entry version 83.
DE   RecName: Full=Chromobox protein homolog 7;
GN   Name=CBX7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=20057165; PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PNS;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION, INTERACTION WITH RING1, AND MUTAGENESIS OF
RP   LYS-31 AND TRP-32.
RX   PubMed=14647293; DOI=10.1038/ncb1077;
RA   Gil J., Bernard D., Martinez D., Beach D.;
RT   "Polycomb CBX7 has a unifying role in cellular lifespan.";
RL   Nat. Cell Biol. 6:67-72(2004).
RN   [4]
RP   INTERACTION WITH RING2.
RX   PubMed=19791798; DOI=10.1021/bi901131u;
RA   Bezsonova I., Walker J.R., Bacik J.P., Duan S., Dhe-Paganon S.,
RA   Arrowsmith C.H.;
RT   "Ring1B contains a ubiquitin-like docking module for interaction with
RT   Cbx proteins.";
RL   Biochemistry 48:10542-10548(2009).
RN   [5]
RP   STRUCTURE BY NMR OF 7-62.
RG   Structural genomics consortium (SGC);
RT   "Solution NMR structure of the chromobox protein homolog 7.";
RL   Submitted (MAR-2008) to the PDB data bank.
CC   -!- FUNCTION: Involved in maintaining the transcriptionally repressive
CC       state of genes. Modifies chromatin, rendering it heritably changed
CC       in its expressibility (By similarity). Regulator of cellular
CC       lifespan by maintaining the repression of CDKN2A, but not by
CC       inducing telomerase activity.
CC   -!- SUBUNIT: Component of the chromatin-associated polycomb complex
CC       (PcG) (By similarity). Interacts with RING1 and RING2, but not
CC       with BMI1, EED or EZH2.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Contains 1 chromo domain.
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DR   EMBL; AL031846; CAB36555.1; -; Genomic_DNA.
DR   EMBL; BC051773; AAH51773.1; -; mRNA.
DR   IPI; IPI00001385; -.
DR   RefSeq; NP_783640.1; -.
DR   UniGene; Hs.356416; -.
DR   PDB; 2K1B; NMR; -; A=7-62.
DR   PDBsum; 2K1B; -.
DR   ProteinModelPortal; O95931; -.
DR   DIP; DIP-44565N; -.
DR   MINT; MINT-4543653; -.
DR   STRING; O95931; -.
DR   PRIDE; O95931; -.
DR   Ensembl; ENST00000216133; ENSP00000216133; ENSG00000100307.
DR   GeneID; 23492; -.
DR   KEGG; hsa:23492; -.
DR   UCSC; uc003axb.1; human.
DR   CTD; 23492; -.
DR   GeneCards; GC22M039518; -.
DR   H-InvDB; HIX0016485; -.
DR   HGNC; HGNC:1557; CBX7.
DR   HPA; CAB011574; -.
DR   MIM; 608457; gene.
DR   PharmGKB; PA26132; -.
DR   eggNOG; prNOG05928; -.
DR   HOGENOM; HBG717546; -.
DR   HOVERGEN; HBG019320; -.
DR   InParanoid; O95931; -.
DR   OMA; EWEPAEQ; -.
DR   OrthoDB; EOG9JDKS9; -.
DR   PhylomeDB; O95931; -.
DR   NextBio; 45855; -.
DR   ArrayExpress; O95931; -.
DR   Bgee; O95931; -.
DR   CleanEx; HS_CBX7; -.
DR   Genevestigator; O95931; -.
DR   GermOnline; ENSG00000100307; Homo sapiens.
DR   GO; GO:0000785; C:chromatin; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0006333; P:chromatin assembly or disassembly; IEA:InterPro.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR017984; Chromo_dom_subgr.
DR   InterPro; IPR000953; Chromodomain.
DR   InterPro; IPR016197; Chromodomain-like.
DR   Pfam; PF00385; Chromo; 1.
DR   PRINTS; PR00504; CHROMODOMAIN.
DR   SMART; SM00298; CHROMO; 1.
DR   SUPFAM; SSF54160; Chromodomain-like; 1.
DR   PROSITE; PS00598; CHROMO_1; 1.
DR   PROSITE; PS50013; CHROMO_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chromatin regulator; Complete proteome; Nucleus;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN         1    251       Chromobox protein homolog 7.
FT                                /FTId=PRO_0000080212.
FT   DOMAIN       11     69       Chromo.
FT   REGION      223    236       Required for cellular lifespan extension.
FT   MUTAGEN      31     31       K->A: Loss of cellular lifespan
FT                                extension.
FT   MUTAGEN      32     32       W->A: Loss of cellular lifespan
FT                                extension.
FT   CONFLICT     77     77       K -> R (in Ref. 2; AAH51773).
FT   CONFLICT    239    239       A -> P (in Ref. 2; AAH51773).
FT   STRAND       14     22
FT   STRAND       25     31
FT   HELIX        37     39
FT   STRAND       42     44
FT   HELIX        51     58
SQ   SEQUENCE   251 AA;  28341 MW;  A90019C1D08812B8 CRC64;
     MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD PRLVMAYEEK
     EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK LCFSLTCPLG SGSPEGVVKA
     GAPELVDKGP LVPTLPFPLR KPRKAHKYLR LSRKKFPPRG PNLESHSHRR ELFLQEPPAP
     DVLQAAGEWE PAAQPPEEEA DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA
     EGFFRDRSGK F
//