ID ACM5_HUMAN Reviewed; 532 AA. AC P08912; Q96RG7; DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 2. DT 05-OCT-2010, entry version 111. DE RecName: Full=Muscarinic acetylcholine receptor M5; GN Name=CHRM5; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=90166521; PubMed=3272174; DOI=10.1016/0896-6273(88)90190-0; RA Bonner T.I., Young A.C., Brann M.R., Buckley N.J.; RT "Cloning and expression of the human and rat m5 muscarinic RT acetylcholine receptor genes."; RL Neuron 1:403-410(1988). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lens epithelium; RA Rae J.L., Shepard A.R.; RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RA Wang H., Yeomans J.; RT "Human muscarinic acetylcholine receptor 5 is localized on 15q13.1 and RT its expression in SH-SY5Y cells."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-526. RC TISSUE=Keratinocyte; RA Arredondo J., Grando S.A.; RT "Cloning cholinergic receptors in human keratinocytes."; RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The muscarinic acetylcholine receptor mediates various CC cellular responses, including inhibition of adenylate cyclase, CC breakdown of phosphoinositides and modulation of potassium CC channels through the action of G proteins. Primary transducing CC effect is Pi turnover. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC Cell junction, synapse, postsynaptic cell membrane; Multi-pass CC membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M80333; AAA51569.1; -; Genomic_DNA. DR EMBL; AF026263; AAB95158.1; -; mRNA. DR EMBL; AB084282; BAB91222.1; -; mRNA. DR EMBL; AF498919; AAM18942.1; -; mRNA. DR EMBL; AF385591; AAK68116.1; -; mRNA. DR IPI; IPI00031710; -. DR PIR; JT0530; JT0530. DR RefSeq; NP_036257.1; -. DR UniGene; Hs.584747; -. DR ProteinModelPortal; P08912; -. DR STRING; P08912; -. DR PRIDE; P08912; -. DR Ensembl; ENST00000327937; ENSP00000331108; ENSG00000184984. DR Ensembl; ENST00000383263; ENSP00000372750; ENSG00000184984. DR GeneID; 1133; -. DR KEGG; hsa:1133; -. DR UCSC; uc001zhk.1; human. DR CTD; 1133; -. DR GeneCards; GC15P034261; -. DR H-InvDB; HIX0012084; -. DR HGNC; HGNC:1954; CHRM5. DR HPA; HPA013172; -. DR MIM; 118496; gene. DR PharmGKB; PA26486; -. DR eggNOG; prNOG12672; -. DR HOGENOM; HBG713567; -. DR HOVERGEN; HBG105720; -. DR InParanoid; P08912; -. DR OMA; RKPAHRA; -. DR OrthoDB; EOG93NB01; -. DR PhylomeDB; P08912; -. DR Reactome; REACT_14797; Signaling by GPCR. DR DrugBank; DB00572; Atropine. DR DrugBank; DB00767; Benzquinamide. DR DrugBank; DB00785; Cryptenamine. DR DrugBank; DB00725; Homatropine Methylbromide. DR DrugBank; DB01403; Methotrimeprazine. DR DrugBank; DB00340; Metixene. DR DrugBank; DB00334; Olanzapine. DR DrugBank; DB00420; Promazine. DR DrugBank; DB01069; Promethazine. DR DrugBank; DB00777; Propiomazine. DR DrugBank; DB00372; Thiethylperazine. DR NextBio; 4712; -. DR ArrayExpress; P08912; -. DR Bgee; P08912; -. DR CleanEx; HS_CHRM5; -. DR Genevestigator; P08912; -. DR GermOnline; ENSG00000184984; Homo sapiens. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004981; F:muscarinic acetylcholine receptor activity; TAS:ProtInc. DR GO; GO:0004435; F:phosphoinositide phospholipase C activity; TAS:ProtInc. DR GO; GO:0008283; P:cell proliferation; TAS:ProtInc. DR GO; GO:0007197; P:inhibition of adenylate cyclase activity by...; TAS:ProtInc. DR InterPro; IPR000276; 7TM_GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR000502; Musac_M5_rcpt. DR InterPro; IPR000995; Musac_rcpt. DR PANTHER; PTHR19266:SF36; Musac_M5_rcpt; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00243; MUSCARINICR. DR PRINTS; PR00542; MUSCRINICM5R. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell junction; Cell membrane; Complete proteome; Disulfide bond; KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; KW Postsynaptic cell membrane; Receptor; Synapse; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1 532 Muscarinic acetylcholine receptor M5. FT /FTId=PRO_0000069042. FT TOPO_DOM 1 29 Extracellular (By similarity). FT TRANSMEM 30 53 Helical; Name=1; (By similarity). FT TOPO_DOM 54 66 Cytoplasmic (By similarity). FT TRANSMEM 67 87 Helical; Name=2; (By similarity). FT TOPO_DOM 88 104 Extracellular (By similarity). FT TRANSMEM 105 126 Helical; Name=3; (By similarity). FT TOPO_DOM 127 146 Cytoplasmic (By similarity). FT TRANSMEM 147 169 Helical; Name=4; (By similarity). FT TOPO_DOM 170 191 Extracellular (By similarity). FT TRANSMEM 192 214 Helical; Name=5; (By similarity). FT TOPO_DOM 215 443 Cytoplasmic (By similarity). FT TRANSMEM 444 464 Helical; Name=6; (By similarity). FT TOPO_DOM 465 478 Extracellular (By similarity). FT TRANSMEM 479 498 Helical; Name=7; (By similarity). FT TOPO_DOM 499 532 Cytoplasmic (By similarity). FT MOD_RES 501 501 Phosphothreonine (Potential). FT MOD_RES 505 505 Phosphothreonine (Potential). FT CARBOHYD 8 8 N-linked (GlcNAc...) (Potential). FT DISULFID 103 183 By similarity. FT CONFLICT 526 526 Q -> P (in Ref. 5). SQ SEQUENCE 532 AA; 60074 MW; EE846186F645DD9B CRC64; MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLISFI LWAPAILCWQ YLVGKRTVPL DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE KRKPAHRALF RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE TEKSDYDTPN YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV KIMPCPFPVA KEPSTKGLNP NPSHQMTKRK RVVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTV NPICYALCNR TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP //