ID   AAMP_HUMAN              Reviewed;         434 AA.
AC   Q13685; Q8WUJ9; Q96H92;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 2.
DT   05-OCT-2010, entry version 85.
DE   RecName: Full=Angio-associated migratory cell protein;
GN   Name=AAMP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Brain;
RX   MEDLINE=95262124; PubMed=7743515;
RA   Beckner M.E., Krutzsch H.C., Stracke M.L., Williams S.T.,
RA   Gallardo J.A., Liotta L.A.;
RT   "Identification of a new immunoglobulin superfamily protein expressed
RT   in blood vessels with a heparin-binding consensus sequence.";
RL   Cancer Res. 55:2140-2149(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=10329261; DOI=10.1006/mvre.1999.2144;
RA   Beckner M.E., Peterson V.A., Moul D.E.;
RT   "Angio-associated migratory cell protein is expressed as an
RT   extracellular protein by blood-vessel-associated mesenchymal cells.";
RL   Microvasc. Res. 57:347-352(1999).
RN   [5]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18634987; DOI=10.1016/j.jacc.2008.03.055;
RA   Vogt F., Zernecke A., Beckner M., Krott N., Bosserhoff A.-K.,
RA   Hoffmann R., Zandvoort M.A.M.J., Jahnke T., Kelm M., Weber C.,
RA   Blindt R.;
RT   "Blockade of angio-associated migratory cell protein inhibits smooth
RT   muscle cell migration and neointima formation in accelerated
RT   atherosclerosis.";
RL   J. Am. Coll. Cardiol. 52:302-311(2008).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
CC   -!- FUNCTION: Plays a role in angiogenesis and cell migration. In
CC       smooth muscle cell migration, may act through the RhoA pathway.
CC   -!- SUBCELLULAR LOCATION: Cell membrane. Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Expressed in metastatic melanoma, liver, skin,
CC       kidney, heart, lung, lymph node, skeletal muscle and brain, and
CC       also in A2058 melanoma cells and activated T cells (at protein
CC       level). Expressed in blood vessels. Strongly expressed in
CC       endothelial cells, cytotrophoblasts, and poorly differentiated.
CC       colon adenocarcinoma cells found in lymphatics.
CC   -!- SIMILARITY: Contains 8 WD repeats.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA68889.1; Type=Erroneous initiation;
CC       Sequence=CAG33036.1; Type=Erroneous initiation;
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DR   EMBL; M95627; AAA68889.1; ALT_INIT; mRNA.
DR   EMBL; CR456755; CAG33036.1; ALT_INIT; mRNA.
DR   EMBL; BC008809; AAH08809.2; -; mRNA.
DR   EMBL; BC020244; AAH20244.1; -; mRNA.
DR   EMBL; BC039866; AAH39866.2; -; mRNA.
DR   IPI; IPI00014481; -.
DR   PIR; I39383; I39383.
DR   RefSeq; NP_001078.2; -.
DR   UniGene; Hs.83347; -.
DR   ProteinModelPortal; Q13685; -.
DR   SMR; Q13685; 57-404.
DR   IntAct; Q13685; 2.
DR   MINT; MINT-1418005; -.
DR   STRING; Q13685; -.
DR   PRIDE; Q13685; -.
DR   Ensembl; ENST00000248450; ENSP00000248450; ENSG00000127837.
DR   GeneID; 14; -.
DR   KEGG; hsa:14; -.
DR   UCSC; uc002vhj.1; human.
DR   CTD; 14; -.
DR   GeneCards; GC02M219092; -.
DR   H-InvDB; HIX0023978; -.
DR   HGNC; HGNC:18; AAMP.
DR   HPA; CAB017717; -.
DR   MIM; 603488; gene.
DR   PharmGKB; PA24365; -.
DR   eggNOG; prNOG05531; -.
DR   HOVERGEN; HBG061307; -.
DR   InParanoid; Q13685; -.
DR   PhylomeDB; Q13685; -.
DR   NextBio; 31; -.
DR   ArrayExpress; Q13685; -.
DR   Bgee; Q13685; -.
DR   CleanEx; HS_AAMP; -.
DR   Genevestigator; Q13685; -.
DR   GermOnline; ENSG00000127837; Homo sapiens.
DR   GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; TAS:ProtInc.
DR   GO; GO:0001525; P:angiogenesis; NAS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0010595; P:positive regulation of endothelial cell mig...; ISS:UniProtKB.
DR   GO; GO:0014909; P:smooth muscle cell migration; IEP:UniProtKB.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR011046; WD40_repeat-like_dom.
DR   InterPro; IPR019782; WD40_repeat_2.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR019781; WD40_repeat_sg.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 2.
DR   Pfam; PF00400; WD40; 6.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; WD40_like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Angiogenesis; Cell membrane; Complete proteome; Cytoplasm;
KW   Developmental protein; Differentiation; Direct protein sequencing;
KW   Membrane; Polymorphism; Repeat; WD repeat.
FT   CHAIN         1    434       Angio-associated migratory cell protein.
FT                                /FTId=PRO_0000050832.
FT   REPEAT       89    129       WD 1.
FT   REPEAT      132    171       WD 2.
FT   REPEAT      173    212       WD 3.
FT   REPEAT      214    254       WD 4.
FT   REPEAT      258    299       WD 5.
FT   REPEAT      315    354       WD 6.
FT   REPEAT      356    395       WD 7.
FT   REPEAT      398    433       WD 8.
FT   COMPBIAS     53     59       Poly-Glu.
FT   VARIANT     250    250       I -> V (in dbSNP:rs2305835).
FT                                /FTId=VAR_037061.
SQ   SEQUENCE   434 AA;  46751 MW;  A7B8314442EBAF15 CRC64;
     MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG
     NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR
     LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM
     EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR
     IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
     ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG
     IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG
     DHKAKVFCVQ RPDR
//